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Chaudhary, Kulbhushan
- NgAgo:A New Genome Editor
Abstract Views :255 |
PDF Views:79
Authors
Affiliations
1 Advanced Centre for Plant Virology, Division of Plant Pathology, Indian Agricultural Research Institute, New Delhi 110 012, IN
2 Department of Plant Pathology, C. P. College of Agriculture, S. D. Agricultural University, S. K. Nagar 385 506, IN
1 Advanced Centre for Plant Virology, Division of Plant Pathology, Indian Agricultural Research Institute, New Delhi 110 012, IN
2 Department of Plant Pathology, C. P. College of Agriculture, S. D. Agricultural University, S. K. Nagar 385 506, IN
Source
Current Science, Vol 112, No 04 (2017), Pagination: 682-683Abstract
Since the last decade, the field of genome engineering and functional genomics has been revolutionized at rapid speed with the development of sequence-specific nucleases (SSNs), such as zinc finger nucleases (ZFN), transcription activator like effector nuclease (TALEN), and clustered regularly interspaced spacer palindromic repeats (CRISPRs).Full Text
- RNA Base Editing:Programmable Protein Machine
Abstract Views :512 |
PDF Views:81
Authors
Affiliations
1 Advanced Centre for Plant Virology, Division of Plant Pathology, ICAR-Indian Agricultural Research Institute, New Delhi 110 012, IN
1 Advanced Centre for Plant Virology, Division of Plant Pathology, ICAR-Indian Agricultural Research Institute, New Delhi 110 012, IN
Source
Current Science, Vol 114, No 09 (2018), Pagination: 1808-1809Abstract
RNA (ribonucleic acid) is a unique molecule which plays important and diverse roles in biology. In cells, RNA is ephemeral; it acts as a mediator, carrying genetic information from the nucleus to the protein-making machinery in the cytoplasm. A point mutation in RNA transcript could make the protein much shorter or larger than normal. Aberrant expression of RNAs effects the regulation of many cellular functions and gene networks. Most human genetic disorders such as sickle cell anaemia are due to just a single base-pair substitution, or by errors in RNA splicing, or its regulation. Precise editing of aberrant RNA provides a platform to correct the errors, without altering the genetic make-up of template DNA.Full Text
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